Gestational diabetes: glibenclamide or metformin?

Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis

OBJECTIVE To summarize short term outcomes in randomized controlled trials comparing glibenclamide or metformin versus insulin or versus each other in women with gestational diabetes requiring drug treatment. DESIGN Systematic review and meta-analysis. ELIGIBILITY CRITERIA FOR SELECTING STUDIES Randomized controlled trials that fulfilled all the following: (1) published as full text; (2) ad...

Glibenclamide and metfoRmin versus stAndard care in gEstational diabeteS (GRACES): a feasibility open label randomised trial

BACKGROUND Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy. We aimed to determine recruitment rate and participant throughput in a randomised trial of glibenclamide compared with standard therapy insulin (added to maximum tolerated metformin) for treatment of GDM. METHODS We conducted an open label feasibility s...

Metformin in Gestational Diabetes Mellitus

Metformin in gestational diabetes mellitus

Metformin in Gestational Diabetes Mellitus

As currently diagnosed, gestational diabetes mellitus (GDM) affects 5–9% of all pregnancies in the United States and is growing in prevalence. 1 It is defined as carbohydrate intolerance of variable severity that is first recognized during pregnancy. Although GDM has been recognized for decades, the potential significance of the condition, as well as criteria for screening and diagnosis , remai...